Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metabolism

ABSTRACT Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) - insulin resistance (IR) and HOMA-β indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-β indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 μU/mL to 8.90 μU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metabolism.

Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) - insulin resistance (IR) and HOMA-ß indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-ß indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 µU/mL to 8.90 µU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

Cut down on the prevalence of cesarean sections in Brazil: a time-series from 2000 to 2017

Cesarean section was developed to reduce maternal-fetal morbidity and mortality, however when performed without scientific evidence it is associated with complications. This study analyses the temporal trend and factors associated with cesarean section in Brazil, its regions and Federation Units between 2000 and 2017. Ecological study. The prevalence of cesarean sections and maternal variables were identified from the Information System on Live Births. The Prais-Winsten method was used for time series analysis. In the whole period there were 53.497.303 births in Brazil, 48.4% by cesarean section. Between 2000 and 2009, the mean cesarean section in Brazil increased from 39.7% (SD 9.8) to 53% (SD 9.4) between 2010 and 2017 with an annual variation of 1.7 p.p (95%CI 1.6; 1.8). There is stability between 2010 and 2017, with a slight decline from 2015 in the Southeast region with an annual variation of -0.9 (95%CI -1.5; 0.0). It is observed that the caesarean section has remained stable in most macro-regions and even decreasing in the southeast and in the group of women with higher education, not adolescents and better prenatal coverage. It is believed that Brazil has reached the plateau in the prevalence of cesarean section (60%) in most states and in the next years there is a decrease in these prevalences.

Regular dental care in preschoolers in rural Southern Brazil.

OBJECTIVE: To evaluate if factors related to the mother's previous guidance on her children's dental health and the school attendance of children influence the regular dental care of preschoolers living in the rural area of a municipality in Southern Brazil. METHODS: A population-based study was conducted with 264 children under five years of age and their mothers. Socioeconomic and behavioral data were collected using a questionnaire, and the children were subjected to dental health tests. The outcome was the regular use of dental services. The main exposure variables were children's care in daycare centers or schools and maternal guidance on the child's dental health. Poisson regression analysis with robust variance adjustment was used to estimate prevalence ratios, considering a 95% confidence interval. RESULTS: The prevalence of regular use was 11.4% (95%CI 7.5-15.2). In the adjusted analysis, the regular use of services was associated with the child attending day care center/school (PR = 2.44; 95%CI 1.38-4.34), and the mother received dental health guidance (PR = 4.13; 95%CI 1.77-9.61), even with control for socioeconomic, maternal and child variables. CONCLUSION: When mothers receive previous information on child dental health care and children attend schools or daycare centers, the likelihood of regular dental appointments in preschoolers living in rural locations increases.

Regular dental care in preschoolers in rural Southern Brazil / Atendimento odontológico regular em pré-escolares da área rural do Sul do Brasil

ABSTRACT OBJECTIVE To evaluate if factors related to the mother's previous guidance on her children's dental health and the school attendance of children influence the regular dental care of preschoolers living in the rural area of a municipality in Southern Brazil. METHODS A population-based study was conducted with 264 children under five years of age and their mothers. Socioeconomic and behavioral data were collected using a questionnaire, and the children were subjected to dental health tests. The outcome was the regular use of dental services. The main exposure variables were children's care in daycare centers or schools and maternal guidance on the child's dental health. Poisson regression analysis with robust variance adjustment was used to estimate prevalence ratios, considering a 95% confidence interval. RESULTS The prevalence of regular use was 11.4% (95%CI 7.5-15.2). In the adjusted analysis, the regular use of services was associated with the child attending day care center/school (PR = 2.44; 95%CI 1.38-4.34), and the mother received dental health guidance (PR = 4.13; 95%CI 1.77-9.61), even with control for socioeconomic, maternal and child variables. CONCLUSION When mothers receive previous information on child dental health care and children attend schools or daycare centers, the likelihood of regular dental appointments in preschoolers living in rural locations increases.

RESUMO OBJETIVO Avaliar se fatores relacionados à orientação prévia da mãe sobre saúde bucal dos seus filhos e a frequência escolar das crianças influenciam o atendimento odontológico regular de pré-escolares moradores da área rural de um município do Sul do Brasil. MÉTODOS Um estudo de base populacional foi conduzido com 264 crianças menores de cinco anos e suas mães. Dados socioeconômicos e comportamentais foram coletados por meio de questionário e as crianças foram submetidas a exames de saúde bucal. O desfecho foi o uso regular de serviços odontológicos. As variáveis de exposição principais foram o atendimento infantil em creches ou escolas e orientação materna sobre a saúde bucal da criança. A análise de regressão de Poisson com ajuste robusto de variância foi utilizada para estimar as razões de prevalência e intervalos de confiança de 95%. RESULTADOS A prevalência de uso regular foi 11,4% (IC95% 7,5-15,2). Na análise ajustada o uso regular de serviços foi associado à criança frequentar creche/escola (RP = 2,44; IC95% 1,38-4,34) e a mãe ter recebido orientação de saúde bucal (RP = 4,13; IC95% 1,77-9,61), mesmo com controle para variáveis socioeconômicas, maternas e da criança. CONCLUSÃO Quando as mães recebem informações prévias sobre os cuidados com a saúde bucal infantil e as crianças frequentam escolas ou creches, aumenta a probabilidade de consultas odontológicas regulares em pré-escolares residentes em localidades rurais.

[Temporal trend and spatial distribution of congenital syphilis in the state of Rio Grande do Sul between 2001 and 2012]. / Tendência temporal e distribuição espacial da sífilis congênita no estado do Rio Grande do Sul entre 2001 e 2012.

The scope of the study was to evaluate the temporal trend and spatial distribution of congenital syphilis (CS) in the state of Rio Grande do Sul. All cases reported by the SINASC/DATASUS between 2001 and 2012 were included. The number of live births was obtained from DATASUS. Incidence rates of CS were grouped according to micro-regions of IBGE and analyzed for the entire period and for triennia. The spatial correlation was analyzed by the global Moran index (I) and the local index. 3,613 cases were reported. Between 2007 and 2012 89 neonates (3.6%) died. Rates varied from to 1.03 in 2001 to 5.1 cases per 1000 live births in 2012, with an annual increase of 0.84 cases per 1000 live births (p < 0.01) and 93.88% of explained variance. The micro-regions were spatially independent (I = 0.06; p = 0.25), with Porto Alegre having the highest incidence (4.19 cases / 1000 live births) and Jaguarão the lowest (0.23 cases / 1000 live births). Micro-regions with significant local spatial dependence were observed. The increase in cases of CS highlights poor prenatal quality care. Identification of the micro-regions with the highest incidence is essential to focus public policy on this health problem.

Objetivou-se avaliar a tendência temporal e a distribuição espacial da Sífilis Congênita (SC) no estado do Rio Grande do Sul. Todos os casos notificados pelo Sistema Nacional de Agravos de Notificação entre 2001 e 2012 foram incluídos. Os números de nascidos vivos foram obtidos do SINASC/DATASUS. As taxas de incidência de SC foram agrupados conforme as microrregiões do IBGE e analisados para todo o período e em triênios. A correlação espacial foi analisada pelo índice de Moran global (I) e local. Foram notificados 3.613 casos. Entre 2007 e 2012 morreram 89 neonatos (3,6%). As taxas de SC variaram de 1,03 em 2001 a 5,1 casos por 1.000 nascidos vivos em 2012, com um incremento anual de 0,84 casos por 1.000 nascidos vivos (p < 0,01) e 93,88% da variação explicada. As microrregiões foram espacialmente independentes (I = 0,06; p = 0,25), tendo Porto Alegre a maior incidência (4,19 casos/1.000 nascidos vivos) e Jaguarão a menor (0,23 casos/1.000 nascidos vivos). Observaram-se microrregiões com dependência espacial local significativa. O aumento dos casos de SC salienta um déficit na qualidade do pré-natal. A identificação das microrregiões com maior incidência é essencial para focalizar as políticas públicas sobre esse tema.

Tendência temporal e distribuição espacial da sífilis congênita no estado do Rio Grande do Sul entre 2001 e 2012 / Temporal trend and spatial distribution of congenital syphilis in the state of Rio Grande do Sul between 2001 and 2012

Resumo Objetivou-se avaliar a tendência temporal e a distribuição espacial da Sífilis Congênita (SC) no estado do Rio Grande do Sul. Todos os casos notificados pelo Sistema Nacional de Agravos de Notificação entre 2001 e 2012 foram incluídos. Os números de nascidos vivos foram obtidos do SINASC/DATASUS. As taxas de incidência de SC foram agrupados conforme as microrregiões do IBGE e analisados para todo o período e em triênios. A correlação espacial foi analisada pelo índice de Moran global (I) e local. Foram notificados 3.613 casos. Entre 2007 e 2012 morreram 89 neonatos (3,6%). As taxas de SC variaram de 1,03 em 2001 a 5,1 casos por 1.000 nascidos vivos em 2012, com um incremento anual de 0,84 casos por 1.000 nascidos vivos (p < 0,01) e 93,88% da variação explicada. As microrregiões foram espacialmente independentes (I = 0,06; p = 0,25), tendo Porto Alegre a maior incidência (4,19 casos/1.000 nascidos vivos) e Jaguarão a menor (0,23 casos/1.000 nascidos vivos). Observaram-se microrregiões com dependência espacial local significativa. O aumento dos casos de SC salienta um déficit na qualidade do pré-natal. A identificação das microrregiões com maior incidência é essencial para focalizar as políticas públicas sobre esse tema.

Abstract The scope of the study was to evaluate the temporal trend and spatial distribution of congenital syphilis (CS) in the state of Rio Grande do Sul. All cases reported by the SINASC/DATASUS between 2001 and 2012 were included. The number of live births was obtained from DATASUS. Incidence rates of CS were grouped according to micro-regions of IBGE and analyzed for the entire period and for triennia. The spatial correlation was analyzed by the global Moran index (I) and the local index. 3,613 cases were reported. Between 2007 and 2012 89 neonates (3.6%) died. Rates varied from to 1.03 in 2001 to 5.1 cases per 1000 live births in 2012, with an annual increase of 0.84 cases per 1000 live births (p < 0.01) and 93.88% of explained variance. The micro-regions were spatially independent (I = 0.06; p = 0.25), with Porto Alegre having the highest incidence (4.19 cases / 1000 live births) and Jaguarão the lowest (0.23 cases / 1000 live births). Micro-regions with significant local spatial dependence were observed. The increase in cases of CS highlights poor prenatal quality care. Identification of the micro-regions with the highest incidence is essential to focus public policy on this health problem.